Human Performance Physiome National Network

Despite advances in the quantification of human physiological responses (the human physiome), in particular, cardiorespiratory responses to exercise testing, database management, standard methodology, and strategic interfacing of such testing results with basic biological data have not kept pace. The Human Performance National Network (HP2N2) will address the following specific aims:

• Survey national expertise in assessing cardiorespiratory responses to exercise (a key element of the human physiome).
• Develop standardized human exercise testing database protocols for national, large-scale, multicenter trials.
• Development of novel exercise-based protocols more suitable for individuals with disease and disability.

Informatics Needs

• Software infrastructure to document and store heterogeneous human physiome data.
• Collaborative tools to enable social networking among heterogeneous researchers (researchers, physicians, physiologists, and computer scientists), open and secure access to information.
• Interview protocol based on Drs. Judy and Gary Olson’s (CBMI collaborators) theory of remote collaboration intended to assess whether the proposed collaboration has any major issues that are likely to lead to failure.
• Software infrastructure for correcting for multisite differences in human exercise data.
• Systems support for data query, visualization and analysis of data.
• Ontology and semantic data integration systems.
• Computational support for data mining.
• Computational biology to fit breath-by-breath data of gas exchange to dynamical models.

The Human Performance Physiome National Network—Founding Members

• Vince Caiozzo, PhD
  Leader of Technology Transfer Unit ICTS
  University of California , Irvine

• John Doyle, PhD
  Professor of Control and Dynamical Systems
  California Institute of Technology
  Letter of Support

• Robert Fahey, MD
  Director, Pediatric Exercise Laboratory
  Yale University
  Letter of Support

• Michael Joyner, MD
  Associate Director CTSA
  Mayo Clinic
  Letter of Support

• Michael Kahn, MD, PhD
  Co-Director Translational Informatics
  University of Colorado, Denver
  Letter of Support

• Benjamin Levine, MD
  Professor of Medicine and Director, Institute of Exercise and Environmental Medicine
  University of Texas , Southwest
  Letter of Support

• Carl Maresh, PhD
  Chair, Department of Exercise Science
  University of Connecticut
  Letter of Support

• Robert Mazzeo, PhD
  Professor of Integrative Physiology
  University of Colorado

• Arthur Weltman, PhD
  Director, Exercise Physiology Graduate Program
  University of Virginia
  Letter of Support