[Mentors]: Michael Demetriou (Neurology) / Marian Waterman (Microbiology & Molecular Genetics)
Project Title: Pre-clinical assessment of Glycan-dependent Immunotherapeutic molecules in mice
Immunotherapy using monoclonal antibodies has been recently developed as a promising approach to treat cancer. Alterations in the addition of carbohydrates to proteins is a near universal feature of cancer, but is not targeted by current immunotherapies. I currently examine the possibility of a novel technology that directs immune cells to kill cancer cells based on expression of altered carbohydrates.