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John Krolewski, MD, PhD
Associate Professor, Pathology and Laboratory Medicine, UC Irvine
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| Current PI funding: NIH (R01-CA056862), Signaling via regulated proteolysis of IFNaR2 (2006-2010)
Rosetta Genomics, Validation of micro RNA based cancer lineage assays (2008)
DOD PCRP (PC073208), Pre-doctoral fellowship support (2008-2011) |
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| Mentoring: Dr. Krolewski is a highly effective mentor whose trainees have proceeded to distinguished academic positions, including Dr. Hai Yan, Assistant Professor of Pathology at Duke University; Dr. Mahesh Mansuhkani, Associate Professor of Pathology at Columbia University; and Dr. Baljit Singh, Associate Professor of Pathology at New York University. Dr. Krolewski is Course Director for Signal Transduction and Growth Control (MBGB) at UC Irvine; He oversees a CLIA-certified clinical lab employing molecular technologies in the diagnosis of disease. He has mentored 10 trainees, with 3 more currently. |
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| Research: Dr. Krolewski studies intracellular signaling and the regulation of normal and neoplastic cell growth. In 1990 Dr. Krolewski discovered and cloned the Tyk2 gene, which led to his long-term interest in the mechanisms of signaling by helical cytokines via the so-called broken receptor' paradigm. Together with his colleagues, Dr. Krolewski translates molecular techniques into diagnostic tools for genetic diseases and cancers. For example, one of his projects focuses on Madindoline A, a natural product which blocks gp130 dimerization and signaling. Dr. Krolewski has received numerous fellowships and awards including the Hirschl/Weill-Caulier Career Scientist Award (1992-1996) and the American Cancer Society Junior Faculty Award (1992-1995). |
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