| |
|
| |
|
|
Wen Hwa Lee, PhD
Donald Bren Professor, Biological Chemistry, UC Irvine
|
| |
| Current PI funding: NIH (R01-CA94170), Transcriptional role of BRCA1 in breast cancer (2008-2012)
NIH (R01-CA107568), Hec1 networks as potential therapeutic targets (2005-2009)
NIH (R01), Mitochondrial roles of SUV3 in premature aging and cancer (2008-2013)
NIH (T32-CA113265), Translational research: Cancer genomic medicine (2007-2012)
Leukemia & Lymphoma Society (6097-08), Rad51 recombinase inhibitors (2007-2010) |
| |
| Mentoring: Dr. Lee's 58 prior trainees include Dr. Helen Chew, Associate Professor of Internal Medicine at UC Davis and Director of the UC Davis Breast Cancer Program; Dr. Yung-Ming Jeng, Assistant Professor of Pathology at the National Taiwan University; and Dr. Dan Riley, Associate Professor of Medicine at UTHSC, San Antonio, whose NIH/NIDDK co-PI grant ĀPathogenic mechanism of polycystic kidney diseaseĀ (2006-2011) received a score of 124 and ranked in the top 0.3 percentile. Dr. Lee is currently mentoring 9 trainees. |
| |
| Research: Among his many accomplishments, Dr. Lee is renowned for identifying and cloning a tumor-suppressor gene that plays a vital role in the cellular battle against cancer. Known as the human retinoblastoma susceptibility gene (RB), it constituted a new class of gene that suppresses the growth of tumors. When functioning at proper levels, RB proteins control the division of normal cells. Although only retinoblastoma, an eye malignancy, had been directly linked to the loss of RB in cells, Dr. Lee and colleagues were able to show that this gene could also be a factor in other cancers. Author/co-author of more than 200 peer-reviewed journal articles, Dr. Lee's numerous research awards and honors include the Outstanding Alumni Award, National Taiwan Normal University (2002); the Presidential Award, SCBA (2001); and the NIH Director Lectureship (1991). |
|
|
