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ICTS Human Performance Lab and

The Pediatric Exercise & Genomics Research Center Seminar Series

Can we Harness the Acute Stress Response to Augment Adoptive Transfer Immunotherapy? 

Richard J Simpson, PhD
Department of Health and Human Performance
University of Houston


Hematopoietic stem cell transplantation (HSCT) is the preferred treatment for many patients with hematologic malignancies. However, HSCT is associated with significant morbidity and mortality especially due to viral infections (i.e. cytomegalovirus, Epstein-Barr virus and adenovirus) and relapse. This presentation will focus on the immuno-enhancing effects of the acute stress response (using dynamic acute exercise as an experimental model) as a means of increasing the efficacy of adoptive transfer immunotherapy - the passive infusion of ex vivo expanded donor-derived or autologous immune cells to a cancer patient recipient. Our early work in this area indicates that exercise can augment the ex-vivo expansion of donor-derived NK-cells and antigen-specific T-cells that could be used in the allogeneic adoptive transfer immunotherapy setting. This may offer a safe and cost-effective method to improve prognosis and reduce mortality in cancer patients after HSCT.


Friday, February 28th, 2014

Hewitt Hall 1st floor Large Conference Room



Lunch will be provided

Please RSVP:  saizik@uci.edu